DEPT LOGO

 Dept. Home Page
 Department Divisions
 Personnel
 Brochures & Newsletters
 Clinical Training Prog.
 Research Training Prog.
 Consultation Services
 Case Studies
 Case of the Month
 Online CME
 Seminars
 Residents Web
 Feedback
 Staff Directory
 Site Administration

Department of Pathology
University of Pittsburgh
School of Medicine
S-417 BST
200 Lothrop Street
Pittsburgh, PA 15261
(412) 648-9550
v-line

 Department of Pathology
 Division of Experiemental Pathology


PRINCIPAL INVESTIGATOR:

Chunsun Dai, M.D., Ph.D.
- Research Assistant Professor of Pathology

Office:

S429 BST.
200 Lothrop St
Pittsburgh, PA 15261
Email: chd21@pitt.edu
Tel: 412-648-9508
Fax: 412-648-1916

  

RESEARCH:

Dr. Dai's research focus on the the role and mechanisms of Wnts in podocyte dysfunction and acute renal failure.

ONLINE RESOURCES:

Dr. Dai's CV
Dr. Dai's NIH BIOGRAPHICAL SKETCH

PUBLICATIONS:

  1. Dai C, Yang J, and Liu Y. 2002. Single injection of Naked plasmid encoding hepatocyte growth factor prevents cell death and ameliorates acute renal failure in mice. J. Am. Soc. Nephrol. 13:411-422.
  2. Li H, Liu ZH, Dai C, Liu D, Li LS. 2002. Triptolide inhibits proinflammatory factor-induced over-expression of class II MHC and B7 molecules in renal tubular epithelial cells. Acta Pharmacol Sin. 23(9):775-81.
  3. Yang J, Dai C, and Liu Y. 2002. Hepatocyte growth factor gene therapy and angiotensin II blockade synergistically attenuates renal interstitial fibrosis in obstructive nephropathy. J. Am. Soc. Nephrol. 13: 2464-2477.
  4. Yang J, Shultz RW, Mars WM, Wegner RE, Li Y, Dai C, Nejak K, Liu Y. 2002. Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy. J Clin Invest. 110(10):1525-38.
  5. Zhang X, Li Y, Dai C, Yang J, Mundel P, Liu Y. 2003. Sp1 and Sp3 transcription factors synergistically regulate HGF receptor gene expression in kidney. Am J Physiol Renal Physiol. 284(1):F82-94.
  6. Dai C, Yang J, and Liu Y. 2003. Transforming Growth Factor- 1 Potentiates Renal Tubular Epithelial Cell Death by a Mechanism Independent of Smad Signaling. J. Biol. Chem, 278: 12537 - 12545.
  7. Dai C, Li Y, Yang J, and Liu Y. 2003. Hepatocyte Growth Factor Preserves Beta Cell Mass and Mitigates Hyperglycemia in Streptozotocin-induced Diabetic Mice. J. Biol. Chem. 278: 27080 – 27087.
  8. Yang J, Dai C, and Liu Y. 2003. Hepatocyte growth factor suppresses renal interstitial myofibroblast activation and intercepts Smad signal transduction. Am J Pathol. 163(2):621-32.
  9. Wang X, Ryter SW, Dai C, Tang ZL, Watkins SC, Yin XM, Song R, and Choi M.K.. 2003. Necrotic cell death in response to oxidant stress involves the activation of the apoptogenic caspase-8/Bid pathway. J. Biol. Chem. 278(31):29184-91.
  10. Li Y, Yang J, Dai C, Carry W and Liu Y. 2003. Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis. J Clin Invest. 112(4):503-16.
  11. Dai C, Liu Y. 2004. Hepatocyte Growth Factor Antagonizes the Profibrotic Action of TGF-beta1 in Mesangial Cells by Stabilizing Smad Transcriptional Corepressor TGIF. J Am Soc Nephrol. 15:1402-12.
  12. Dai C, Yang J, Bastacky S, Xia J, Li Y, and Liu Y. 2004. Intravenous Administration of Hepatocyte Growth Factor Gene Ameliorates Diabetic Nephropathy in Mice. J. Am. Soc. Nephrol. 15: 2637 – 2647.
  13. Yang J, Dai C, and Liu Y. 2005. A novel mechanism by which hepatocyte growth factor blocks tubular epithelial to mesenchymal transition. J. Am. Soc. Nephrol. 16: 68-78.
  14. Li Y, Spataro BC, Yang J, Dai C, and Liu Y. 2005. 1,25-Dihydroxyvitamin D3 inhibits renal interstitial myofibroblast activation by inducing hepatocyte growth factor expression. Kidney Int. 68(4):1500-10.
  15. Dai C, Huh CG, Thorgeirsson SS, and Liu Y. 2005. Beta cell-specific ablation of the HGF receptor results in reduced islet size, impaired insulin secretion and glucose intolerance. Am. J. Pathol. 167(2):429-36.
  16. Wen X, Li Y, Hu K, Dai C and Liu Y. 2005. Hepatocyte Growth Factor Receptor Signaling Mediates the Anti-Fibrotic Action of 9-cis-Retinoic Acid in Glomerular Mesangial Cells. Am J Pathol. 167(4):947-57.
  17. Li Y, Wen X, Spataro BC, Hu K, Dai C, Liu Y. 2006. Hepatocyte growth factor is a downstream effector that mediates the antifibrotic action of peroxisome proliferator-activated receptor-gamma agonists. J. Am. Soc. Nephrol. 17(1):54-65.
  18. Giannopoulou M, Iszkula SC, Dai C, Tan X, Yang J, Michalopoulos GK, and Liu Y. 2006. Distinctive role of stat3 and Erk-1/2 activation in mediating interferon-. inhibition of TGF-â1 action. Am J Physiol Renal Physiol. 290:F1234-1240.
  19. Xia J*, Dai C*, Michalopoulos GK, and Liu Y. 2006. Hepatocyte growth factor inhibits liver fibrosis induced by bile duct ligation in mice mediating by blocking bile duct epithelial cell EMT. Am J Pathol. 168:1500- 1512. * These two authors co-contributed to this paper.
  20. Dai C, Stolz DB, Bastacky SI., St-Arnaud R, Holzman LB., Wu C, Dedhar S, and Liu Y. 2006. Essential role of integrin-linked kinase in podocyte biology: bridging the integrin and slit diaphragm signaling. J. Am. Soc. Nephrol. 17:2164-2175.
  21. Apte, U., Zeng, G., Muller, P., Tan, X., Micsenyi, A., Cieply, B., Dai, C., Liu, Y., Kaestner, K.H., and Monga, S.P. 2006. Activation of Wnt/beta-catenin pathway during hepatocyte growth factor- induced hepatomegaly in mice. Hepatology 44:992-1002.
  22. Li Y., Dai C, Wu C., and Liu Y. 2007. PINCH-1 promotes tubular epithelial to mesenchymal transition through interacting with integrin-linked kinase. J. Am. Soc. Nephrol. 18: 2534-2543.
  23. Li Y, Kang YS, Dai C, Kiss L, Wen X, and Liu Y. 2008. Epithelial-to-mesenchymal transition is a potential pathway leading to podocyte dysfunction and proteinuria. Am J Pathol. 172(2):299-308.
  24. Giannopoulou M*, Dai C*, Tan X*, Wen X, Michalopoulos GK, and Liu Y. 2008. Hepatocyte growth factor exerts its anti-inflammatory action by disrupting nuclear factor-kappaB signaling. Am J Pathol. 173(1): 30–41. “*”: These authors co-contributed to this paper.

Copyright 1995-2009, Department of Pathology
University of Pittsburgh School of Medicine