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Department of Pathology
University of Pittsburgh
School of Medicine
S-417 BST
200 Lothrop Street
Pittsburgh, PA 15261
(412) 648-9550


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 Department of Pathology
 Division of Experiemental Pathology



PRINCIPAL INVESTIGATOR:






Eric Lagasse, Pharm.D., Ph.D.

- Associate Professor of Pathology







Office:

McGowan Institute for Regenerative Medicine University of Pittsburgh
450 Technology Drive
450 Technology Drive
Pittsburgh, PA 15219
Email: Lagasse@pitt.edu
Tel: 412-624-5285
Fax: 412-624-5363

  

RESEARCH:

Dr. Lagasse research is focused primarily on stem cell biology and cell-based therapy for a variety of diseases including cancer. Specific areas of interest comprise cell based therapy for liver disease, ectopic organogenesis, bioartificial tumors development and identification of normal and cancer stem cells.

For more information, please go to Dr. Lagasse's group web site at:
http://www.mirm.pitt.edu/lagasse/default.asp

PUBLICATIONS:

  1. Lagasse E. (2007). Liver Stem Cells. Principles of Tissue Engineering, 3rd Edition. Edited by R. Lanza, R. Langer and J. Vacanti. Elsevier/academic press. Chapter 47.695-705.
  2. Omidvar N., Kogan S., Beurlet S., le Pogam C., Janin A., West R., Noguera ME, Reboul M., Soulie A., Leboeuf C., Setterblad N., Felsher D., Lagasse E., Mohamedali A., Shaun N., Thomas B., Fenaux P., Fontenay M., Pla M., Mufti G., Irving Weissman I.L., Chomienne C. and Padua R.A. (2007). BCL-2 and Mutant NRAS Interact Physically and Functionally in a Mouse Model of Progressive Myelodysplasia. Cancer Research. 67:11657- 11667.
  3. Rajasekhar V. K., Dalerba P., Passegu E., Lagasse E., Najbauer J. (2008). Meeting report. The 5th International Society for Stem Cell Research (ISSCR) Annual Meeting, June 2007. Stem Cells. 26:292-298.
  4. Lagasse E. (2008). Cancer Stem Cells with Genetic Instability: The Best Vehicle with the Best Engine for Cancer. Gene Therapy. 15:136-142.
  5. Xiong A., Austin W.T., Lagasse E., Uchida N., Tamaki S., Bordier B., Weissman I.L. Glenn JS and Millan M. (2008). Isolation of Human Fetal Liver Progenitors and their Enhanced Proliferation by 3-Dimensional Co-culture with Endothelial Cells. Tissue Eng. Part A. 2008 Apr 23.
  6. Odoux C., Fohrer F., Hoppo T., Guzik T., Stolz D.B., Lewis D.W., Gollin S.M., Gamblin T.C., Geller D.A., and Lagasse E. (2008). A Stochastic Model for Cancer Stem Cell Origin. Cancer Research. 68: 6932-41.
  7. Teisanu, R.M., Lagasse E., Whitesides J. and Stripp B. R. (2008). Prospective Isolation of Bronchiolar Stem Cells. Stem Cells. 27(3):612- 22.
  8. Manohar R. and Lagasse E. (2009). Transdetermination: a new trend in cellular reprogramming. Molecular Therapy. 17 (6): 936- 938.
  9. Chandler J. and Lagasse E. Cancerous Stem Cells: Deviant Stem Cells with Cancer Causing Misbehavior. Stem Cell Research & Therapy. (2010). 1 (2): 13.
  10. Hoppo, T., Komori, J. Manohar R., Stolz D.B. and Lagasse E. Rescue of Lethal hepatic failure by hepatized lymph nodes in mice. Gastroenterology. 140 (2) 656-666.
  11. Soto-Gutierrez A., Zhang L., Medberry C., Fukumitsu K., Faulk D., Jiang H., Reing J., Gramignoli R., Komori J., Ross M., Nagaya M., Lagasse E., Stolz D., Strom S.C., Fox I.J., and Badylak S. A Whole Organ Regenerative Medicine Approach for Liver Replacement. Tissue Engineering Part C. (2011). In press.

Copyright 1995-2009, Department of Pathology
University of Pittsburgh School of Medicine