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PRINCIPAL INVESTIGATOR:
Galina V. Shurin, PhD
- Research Assistant Professor
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Office:
S732, Scaife Hall
Department of Pathology
3550 Terrace Street
Pittsburgh, PA 15261
Email: shuringv@upmc.edu
Tel: 412-648-9841, or 412-648-9831
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RESEARCH:
Dr.Shurin's research interest is focused on studies of a therapeutic approaches on incorporation of low-dose chemotherapy into vaccine therapy. The main hypothesis is that low-dose chemotherapy might modify immunogenecity of the tumor microenvironment and the immonotherapeutic component might then target primary and metastatic tumor and induce specific antitumor immune memory.
PUBLICATIONS:
- Tourkova IL, Shurin GV, Wei S, Shurin MR. Small rho GTPases mediate tumor-induced inhibition of endocytic activity of dendritic cells. J. Immunol, 178(12):7787-7793, 2007.
- Zhong H, Han B, Tourkova I.L, Lokshin A, Rosenbloom A, Shurin MR, Shurin GV. Low-Dose Paclitaxel Prior to Intratumoral Dendritic Cell Vaccine Modulates Intratumoral Cytokine Network and Lung Cancer Growth. Clinical Cancer Research, 13(18):5455-5462, 2007.
- Aalamian M, Chatta GS, Shurin MR, Huland E, Huland H, Shurin GV. Inhibition of dendritic cell generation and function by serum from prostate cancer patients: Correlation with Serum Free PSA. Advances in Exp. Medicine and Biology, 601:173-182, 2007.
- Shurin GV, Yurkovetsky ZR, Chatta GS, Tourkova IL, Shurin MR, Lokshin AE. Dynamic alteration of soluble serum biomarkers in healthy aging. Cytokine, 39(2):123-129, 2007.
- Shurin GV, Tourkova IL, Shurin MR. Low-dose chemotherapeutic agents regulate small RhoGTPase activity in dendritic cells. J. Immunotherapy. 31(5):491-499, 2008.
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