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Department of Pathology
University of Pittsburgh
School of Medicine
S-417 BST
200 Lothrop Street
Pittsburgh, PA 15261
(412) 648-9550


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 Department of Pathology
 Division of Experiemental Pathology



HEPATIC PATHOPHYSIOLOGY LABORATORY

Gang Zeng, MD, PhD, Post Doctoral Fellow

With background in medicine and molecular biology, Dr. Zeng's research has focused on understanding of the essential role of Hepatocyte nuclear factor-alpha (HNF4 ), -catenin, and histone acetyltransferase p300/CBP in liver development, organogenesis, and maintenance of hepatocyte homeostasis.

Publications:

  1. Cieply B, Zeng G, Proverbs-Singh T, Geller DA, Monga SP. Unique phenotype of hepatocellular cancers with exon-3 mutations in beta-catenin gene. Hepatology. 2008 Oct 24. [Epub ahead of print]
  2. Zeng G, Bueno M, Camachos CJ, Ramaswami B, Luo C, Randhawa P. Validation of BKV large T-antigen ATP-binding site as a target for drug discovery. Antiviral Res. 2009 Feb;81(2):184-7. Epub 2008 Dec 11.
  3. Zeng G, Apte U, Cieply B, Singh S, Monga SP. siRNA-mediated beta-catenin knockdown in human hepatoma cells results in decreased growth and survival.
  4. Apte U, Zeng G, Thompson MD, Muller P, Micsenyi A, Cieply B, Kaestner KH, Monga SP. beta-Catenin is critical for early postnatal liver growth. Am J Physiol Gastrointest Liver Physiol. 2007 Jun;292(6):G1578-85. Epub 2007 Mar 1.
  5. Behari J, Zeng G, Otruba W, Thompson MD, Muller P, Micsenyi A, Sekhon SS, Leoni L, Monga SP. R-Etodolac decreases beta-catenin levels along with survival and proliferation of hepatoma cells. J Hepatol. 2007 May;46(5):849-57. Epub 2006 Dec 21.
  6. Zeng G, Awan F, Otruba W, Muller P, Apte U, Tan X, Gandhi C, Demetris AJ, Monga SP. Wnt'er in liver: expression of Wnt and frizzled genes in mouse. Hepatology. 2007 Jan;45(1):195-204.
  7. Apte U, Zeng G, Muller P, Tan X, Micsenyi A, Cieply B, Dai C, Liu Y, Kaestner KH, Monga SP. Activation of Wnt/beta-catenin pathway during hepatocyte growth factor-induced hepatomegaly in mice. Hepatology. 2006 Oct;44(4):992-1002.
  8. Zeng G, Apte U, Micsenyi A, Bell A, Monga SP. Tyrosine residues 654 and 670 in beta-catenin are crucial in regulation of Met-beta-catenin interactions. Exp Cell Res. 2006 Nov 1;312(18):3620-30. Epub 2006 Aug 10.
  9. Zeng G, Germinaro M, Micsenyi A, Monga NK, Bell A, Sood A, Malhotra V, Sood N, Midda V, Monga DK, Kokkinakis DM, Monga SP. Aberrant Wnt/beta-catenin signaling in pancreatic adenocarcinoma. Neoplasia. 2006 Apr;8(4):279-89.

Copyright 1995-2009, Department of Pathology
University of Pittsburgh School of Medicine