CANCER BIOLOGY LECTURE I




SQUAMOUS EPITHELIUM

SKIN:

The multiple functions of the skin are reflected in its complex structure. Like the esophagus, it has upward-projecting papillae. The narrow tongues of the squamous epidermis that project downward between papillae are called rete pegs. The squamous epithelium itself shows a cornified or horny superficial layer of dead keratinized cells. This stratum corneum generally has a basket-weave pattern in routine histologic preparations. Beneath the epidermis are, from top to bottom, are:

  • The papillary dermis - loose connective tissue carrying vessels and nerves
  • The reticular dermis - a layer of heavy, strong collagen fibers
  • The subcutaneous adipose tissue.

The idea of repeating units is helpful in understanding the skin, not only because of its regular alteration of papillae and rete pegs, but because the skin has a regular scattering of adnexa, or accessory structures. In hair-bearing skin, these are organized together in the pilosebaceous unit. It is composed of not only the hair shaft and the onion-bulb-shaped sheath of cells which create the protein matrix of hair, but also the sebaceous gland which secretes oily substances into the hair follicle and the erector pili muscle. The eccrine, or sweat glands, usually lie nearby and empty into their own ductal system.