CANCER BIOLOGY LECTURE I




GLANDULAR EPITHELIA

BREAST:

We interrupt our survey of the gastrointestinal tract to consider the duct-and-acinus architecture of the breast, which will be helpful in understanding several other tissues. The acinus is a circlet of cells grouped around a small lumen. Inconspicuously small, vacuolated myoepithelial cells rim acini and small ducts to squeeze the secretions on their way. A small duct called the terminal duct in the breast is connected to the lumen. Several acini and their terminal ducts will drain into a larger duct; this grouping of acini, terminal ducts and ducts serving them is a lobule. The relationship of large ducts, terminal ducts and acini is that of a tree trunk, branches, and leaves. The lobule is the most easily appreciated unit structure of the breast, and it is much more easily seen than the similar structures in other tissues because it is embedded in almost transparent fat. Drawing an imaginary line around the other limits of a lobule should give a rounded outline, like a well-pruned tree.